les transporteurs de meacutedicaments in vitro
2018.2.1 Les premières études ayant évalué in vitro l’absorption par l’entérocyte de l’acide déshydroascorbique avaient démontré un transport possible via les transporteurs du glucose GLUT 1, GLUT3 et GLUT4 mais pas par le GLUT5 ni par le SGLT1 [15]. Cependant, seuls les transporteurs SGLT1, GLUT2 et GLUT5 sont exprimés dans
Read More
Principles and Experimental Considerations for In Vitro
2021.7.17 Asymmetrical transport across a monolayer of polarized cells is called vectorial transport, and in this process the role of ABC transporters is significant for intestinal absorption as well as hepato-biliary and urinary excretion of drugs.
Read More
In Vitro Methodologies to Assess Potential for Transporter
2021.6.8 Among in vitro systems used to study drug transport and metabolism, cellular models have played a crucial role owing to their versatility and physiological relevance. Earlier drug–transporter and drug–enzyme interaction studies relied on primary cells isolated from the liver, intestinal mucosal, or brain capillary endothelium cells as well ...
Read More
In vitro methods in drug transporter interaction assessment
2014.6.1 In this paper the four predominantly used in vitro methods are discussed: vesicular transport, ATPase, cellular uptake and monolayer assay. Assays with membrane preparations The substrate binding sites of efflux transporters face the cytoplasm and/or cytoplasmic leaflet, and are freely accessible to high passive permeability compounds
Read More
Transporter-mediated drug–drug interactions - ScienceDirect
2021.9.1 The in vitro evaluation for TMDDI is one of the keys for ensuring succese of pharmaceutical innovation. •. TMDDI related regulatory guidelines by the Drug Administration Agencies were analyzed. •. Study design, data analysis, results interpretation, and evaluation strategies were presented with case studies. Abstract.
Read More
Findings on In Vitro Transporter-Mediated Drug Interactions
2022.9.29 Findings on In Vitro Transporter-Mediated Drug Interactions and Their Follow-Up Actions for Labeling: Analysis of Drugs Approved by US FDA between 2017 and 2021. Kyeong-Ryoon Lee, 1,2 Ji-Eun Chang, 3 Jongmin Yoon, 4 Hyojeong Jin, 4 and Yoon-Jee Chae 4,5,* Micheline Piquette-Miller, Academic Editor.
Read More
In vitro methods to support transporter evaluation in drug
2020.7.13 This white paper addresses current approaches and knowledge gaps concerning methods to assess the role of transport proteins in drug/metabolite disposition in humans. The discussion focuses on in vitro tools to address key questions in drug development, including vesicle- and cell-based systems.
Read More
In Vitro Methods to Support Transporter Evaluation in Drug Discovery ...
2013.4.10 In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development. K L R Brouwer, D Keppler, K A Hoffmaster, D A J Bow, Y Cheng, Y Lai, J E Palm, B Stieger, R Evers, International Transporter Consortium. First published: 10 April 2013. doi/10.1038/clpt.2013.81. Citations: 46. Read the full text. PDF. Tools.
Read More
Nos partenaires - fournisseur produits-Ribori Instrumentation
Ses rhéomètres capillaires permettent de répondre aux exigences les plus élevées en termes de taux de ciaillement. Retrouvez sur cette page, l'ensemble de nos partenaires fournisseurs d'instrumentations scientifiques. Linseis, 3P
Read More
Les transporteurs de cations MAGAZINE
Figure 1. Rôle des transporteurs de cations organiques (OCT) dans la clairance des monoamines dans le cerveau et mécanisme d’action du cyanome. Les monoamines (sérotonine, norépinéphrine et dopamine) agissent sur des récepteurs spécifiques.
Read More
les transporteurs de meacutedicaments in vitro
2018.2.1 Les premières études ayant évalué in vitro l’absorption par l’entérocyte de l’acide déshydroascorbique avaient démontré un transport possible via les transporteurs du glucose GLUT 1, GLUT3 et GLUT4 mais pas par le GLUT5 ni par le SGLT1 [15]. Cependant, seuls les transporteurs SGLT1, GLUT2 et GLUT5 sont exprimés dans
Read More
Principles and Experimental Considerations for In Vitro
2021.7.17 Asymmetrical transport across a monolayer of polarized cells is called vectorial transport, and in this process the role of ABC transporters is significant for intestinal absorption as well as hepato-biliary and urinary excretion of drugs.
Read More
In Vitro Methodologies to Assess Potential for Transporter
2021.6.8 Among in vitro systems used to study drug transport and metabolism, cellular models have played a crucial role owing to their versatility and physiological relevance. Earlier drug–transporter and drug–enzyme interaction studies relied on primary cells isolated from the liver, intestinal mucosal, or brain capillary endothelium cells as well ...
Read More
In vitro methods in drug transporter interaction assessment
2014.6.1 In this paper the four predominantly used in vitro methods are discussed: vesicular transport, ATPase, cellular uptake and monolayer assay. Assays with membrane preparations The substrate binding sites of efflux transporters face the cytoplasm and/or cytoplasmic leaflet, and are freely accessible to high passive permeability compounds
Read More
Transporter-mediated drug–drug interactions - ScienceDirect
2021.9.1 The in vitro evaluation for TMDDI is one of the keys for ensuring succese of pharmaceutical innovation. •. TMDDI related regulatory guidelines by the Drug Administration Agencies were analyzed. •. Study design, data analysis, results interpretation, and evaluation strategies were presented with case studies. Abstract.
Read More
Findings on In Vitro Transporter-Mediated Drug Interactions
2022.9.29 Findings on In Vitro Transporter-Mediated Drug Interactions and Their Follow-Up Actions for Labeling: Analysis of Drugs Approved by US FDA between 2017 and 2021. Kyeong-Ryoon Lee, 1,2 Ji-Eun Chang, 3 Jongmin Yoon, 4 Hyojeong Jin, 4 and Yoon-Jee Chae 4,5,* Micheline Piquette-Miller, Academic Editor.
Read More
In vitro methods to support transporter evaluation in drug
2020.7.13 This white paper addresses current approaches and knowledge gaps concerning methods to assess the role of transport proteins in drug/metabolite disposition in humans. The discussion focuses on in vitro tools to address key questions in drug development, including vesicle- and cell-based systems.
Read More
In Vitro Methods to Support Transporter Evaluation in Drug Discovery ...
2013.4.10 In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development. K L R Brouwer, D Keppler, K A Hoffmaster, D A J Bow, Y Cheng, Y Lai, J E Palm, B Stieger, R Evers, International Transporter Consortium. First published: 10 April 2013. doi/10.1038/clpt.2013.81. Citations: 46. Read the full text. PDF. Tools.
Read More
Nos partenaires - fournisseur produits-Ribori Instrumentation
Ses rhéomètres capillaires permettent de répondre aux exigences les plus élevées en termes de taux de ciaillement. Retrouvez sur cette page, l'ensemble de nos partenaires fournisseurs d'instrumentations scientifiques. Linseis, 3P
Read More
Les transporteurs de cations MAGAZINE
Figure 1. Rôle des transporteurs de cations organiques (OCT) dans la clairance des monoamines dans le cerveau et mécanisme d’action du cyanome. Les monoamines (sérotonine, norépinéphrine et dopamine) agissent sur des récepteurs spécifiques.
Read More
les transporteurs de meacutedicaments in vitro
2018.2.1 Les premières études ayant évalué in vitro l’absorption par l’entérocyte de l’acide déshydroascorbique avaient démontré un transport possible via les transporteurs du glucose GLUT 1, GLUT3 et GLUT4 mais pas par le GLUT5 ni par le SGLT1 [15]. Cependant, seuls les transporteurs SGLT1, GLUT2 et GLUT5 sont exprimés dans
Read More
Principles and Experimental Considerations for In Vitro
2021.7.17 Asymmetrical transport across a monolayer of polarized cells is called vectorial transport, and in this process the role of ABC transporters is significant for intestinal absorption as well as hepato-biliary and urinary excretion of drugs.
Read More
In Vitro Methodologies to Assess Potential for Transporter
2021.6.8 Among in vitro systems used to study drug transport and metabolism, cellular models have played a crucial role owing to their versatility and physiological relevance. Earlier drug–transporter and drug–enzyme interaction studies relied on primary cells isolated from the liver, intestinal mucosal, or brain capillary endothelium cells as well ...
Read More
In vitro methods in drug transporter interaction assessment
2014.6.1 In this paper the four predominantly used in vitro methods are discussed: vesicular transport, ATPase, cellular uptake and monolayer assay. Assays with membrane preparations The substrate binding sites of efflux transporters face the cytoplasm and/or cytoplasmic leaflet, and are freely accessible to high passive permeability compounds
Read More
Transporter-mediated drug–drug interactions - ScienceDirect
2021.9.1 The in vitro evaluation for TMDDI is one of the keys for ensuring succese of pharmaceutical innovation. •. TMDDI related regulatory guidelines by the Drug Administration Agencies were analyzed. •. Study design, data analysis, results interpretation, and evaluation strategies were presented with case studies. Abstract.
Read More
Findings on In Vitro Transporter-Mediated Drug Interactions
2022.9.29 Findings on In Vitro Transporter-Mediated Drug Interactions and Their Follow-Up Actions for Labeling: Analysis of Drugs Approved by US FDA between 2017 and 2021. Kyeong-Ryoon Lee, 1,2 Ji-Eun Chang, 3 Jongmin Yoon, 4 Hyojeong Jin, 4 and Yoon-Jee Chae 4,5,* Micheline Piquette-Miller, Academic Editor.
Read More
In vitro methods to support transporter evaluation in drug
2020.7.13 This white paper addresses current approaches and knowledge gaps concerning methods to assess the role of transport proteins in drug/metabolite disposition in humans. The discussion focuses on in vitro tools to address key questions in drug development, including vesicle- and cell-based systems.
Read More
In Vitro Methods to Support Transporter Evaluation in Drug Discovery ...
2013.4.10 In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development. K L R Brouwer, D Keppler, K A Hoffmaster, D A J Bow, Y Cheng, Y Lai, J E Palm, B Stieger, R Evers, International Transporter Consortium. First published: 10 April 2013. doi/10.1038/clpt.2013.81. Citations: 46. Read the full text. PDF. Tools.
Read More
Nos partenaires - fournisseur produits-Ribori Instrumentation
Ses rhéomètres capillaires permettent de répondre aux exigences les plus élevées en termes de taux de ciaillement. Retrouvez sur cette page, l'ensemble de nos partenaires fournisseurs d'instrumentations scientifiques. Linseis, 3P
Read More
Les transporteurs de cations MAGAZINE
Figure 1. Rôle des transporteurs de cations organiques (OCT) dans la clairance des monoamines dans le cerveau et mécanisme d’action du cyanome. Les monoamines (sérotonine, norépinéphrine et dopamine) agissent sur des récepteurs spécifiques.
Read More
les transporteurs de meacutedicaments in vitro
2018.2.1 Les premières études ayant évalué in vitro l’absorption par l’entérocyte de l’acide déshydroascorbique avaient démontré un transport possible via les transporteurs du glucose GLUT 1, GLUT3 et GLUT4 mais pas par le GLUT5 ni par le SGLT1 [15]. Cependant, seuls les transporteurs SGLT1, GLUT2 et GLUT5 sont exprimés dans
Read More
Principles and Experimental Considerations for In Vitro
2021.7.17 Asymmetrical transport across a monolayer of polarized cells is called vectorial transport, and in this process the role of ABC transporters is significant for intestinal absorption as well as hepato-biliary and urinary excretion of drugs.
Read More
In Vitro Methodologies to Assess Potential for Transporter
2021.6.8 Among in vitro systems used to study drug transport and metabolism, cellular models have played a crucial role owing to their versatility and physiological relevance. Earlier drug–transporter and drug–enzyme interaction studies relied on primary cells isolated from the liver, intestinal mucosal, or brain capillary endothelium cells as well ...
Read More
In vitro methods in drug transporter interaction assessment
2014.6.1 In this paper the four predominantly used in vitro methods are discussed: vesicular transport, ATPase, cellular uptake and monolayer assay. Assays with membrane preparations The substrate binding sites of efflux transporters face the cytoplasm and/or cytoplasmic leaflet, and are freely accessible to high passive permeability compounds
Read More
Transporter-mediated drug–drug interactions - ScienceDirect
2021.9.1 The in vitro evaluation for TMDDI is one of the keys for ensuring succese of pharmaceutical innovation. •. TMDDI related regulatory guidelines by the Drug Administration Agencies were analyzed. •. Study design, data analysis, results interpretation, and evaluation strategies were presented with case studies. Abstract.
Read More
Findings on In Vitro Transporter-Mediated Drug Interactions
2022.9.29 Findings on In Vitro Transporter-Mediated Drug Interactions and Their Follow-Up Actions for Labeling: Analysis of Drugs Approved by US FDA between 2017 and 2021. Kyeong-Ryoon Lee, 1,2 Ji-Eun Chang, 3 Jongmin Yoon, 4 Hyojeong Jin, 4 and Yoon-Jee Chae 4,5,* Micheline Piquette-Miller, Academic Editor.
Read More
In vitro methods to support transporter evaluation in drug
2020.7.13 This white paper addresses current approaches and knowledge gaps concerning methods to assess the role of transport proteins in drug/metabolite disposition in humans. The discussion focuses on in vitro tools to address key questions in drug development, including vesicle- and cell-based systems.
Read More
In Vitro Methods to Support Transporter Evaluation in Drug Discovery ...
2013.4.10 In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development. K L R Brouwer, D Keppler, K A Hoffmaster, D A J Bow, Y Cheng, Y Lai, J E Palm, B Stieger, R Evers, International Transporter Consortium. First published: 10 April 2013. doi/10.1038/clpt.2013.81. Citations: 46. Read the full text. PDF. Tools.
Read More
Nos partenaires - fournisseur produits-Ribori Instrumentation
Ses rhéomètres capillaires permettent de répondre aux exigences les plus élevées en termes de taux de ciaillement. Retrouvez sur cette page, l'ensemble de nos partenaires fournisseurs d'instrumentations scientifiques. Linseis, 3P
Read More
Les transporteurs de cations MAGAZINE
Figure 1. Rôle des transporteurs de cations organiques (OCT) dans la clairance des monoamines dans le cerveau et mécanisme d’action du cyanome. Les monoamines (sérotonine, norépinéphrine et dopamine) agissent sur des récepteurs spécifiques.
Read More